But Mata takes his place alongside Jesse Lingard and Anthony Martial in the attacking three behind Zlatan Ibrahimovic.

Michael Carrick is only fit enough to start from the bench after coming off with a knock against St Etienne on Wednesday.

Captain Wayne Rooney is also named as a substitute.

Man Utd: De Gea, Valencia, Bailly, Smalling, Rojo, Herrera, Pogba, Mata, Lingard, Martial, Ibrahimovic 

Subs: Romero, Blind, Young Fellaini, Carrick, Rooney, Rashford

Southampton: Forster; Cédric, Yoshida, Stephens, Bertrand; Romeu, Davis, Ward-Prowse, Tadić; Redmond, Gabbiadini

Subs: Hassen, Long, Rodriguez, Caceres, Boufal, Hojbjerg, McQueen.